Belief in permanence is the greatest folly of the human mind.
We are impermanent phenomena. We change from moment to moment without control or intention. Our bodies are similar to chemical reactions in a test tube. They begin, proceed and end. All this occurs according to physical and chemical laws of energy and matter. That's it!
Living a happy and compassionate life with the constant awareness of this reality takes practice. Folly is the absence of practice and is a waste of human intelligence.